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Optimal Allosteric Stabilization Sites Using Contact Stabilization Analysis

Proteins can be destabilized by a number of environmental factors such as temperature, pH and mutation. The ability to subsequently restore function under these conditions by adding small molecule stabilizers, or by introducing disulfide bonds, would be a very powerful tool, but the physical princip...

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Bibliografische gegevens
Gepubliceerd in:J Comput Chem
Hoofdauteurs: Dickson, Alex, Bailey, Christopher T., Karanicolas, John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403592/
https://ncbi.nlm.nih.gov/pubmed/27774625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.24517
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