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Optimal Allosteric Stabilization Sites Using Contact Stabilization Analysis
Proteins can be destabilized by a number of environmental factors such as temperature, pH and mutation. The ability to subsequently restore function under these conditions by adding small molecule stabilizers, or by introducing disulfide bonds, would be a very powerful tool, but the physical princip...
Gardado en:
| Publicado en: | J Comput Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5403592/ https://ncbi.nlm.nih.gov/pubmed/27774625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.24517 |
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