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Optimal Allosteric Stabilization Sites Using Contact Stabilization Analysis
Proteins can be destabilized by a number of environmental factors such as temperature, pH and mutation. The ability to subsequently restore function under these conditions by adding small molecule stabilizers, or by introducing disulfide bonds, would be a very powerful tool, but the physical princip...
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| Publicado no: | J Comput Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5403592/ https://ncbi.nlm.nih.gov/pubmed/27774625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.24517 |
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