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Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor
BACE1 is a major therapeutic target for prevention and treatment of Alzheimer’s disease. Developing inhibitors that can selectively target BACE1 in favor of other proteases, especially cathepsin D (CatD), has presented significant challenges. Here we investigate the conformational dynamics and proto...
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| Publicado no: | J Comput Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5403572/ https://ncbi.nlm.nih.gov/pubmed/28370344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.24719 |
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