Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S

Major histocompatibility complex class II (MHCII)-restricted antigen priming of CD4(+) T cells is both involved in adaptive immune responses and the pathogenesis of autoimmune diseases. Degradation of invariant chain Ii, a protein that prevents premature peptide loading, is a prerequisite for nascen...

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Publicat a:Front Immunol
Autors principals: Theron, Michel, Bentley, Darren, Nagel, Sandra, Manchester, Marianne, Gerg, Michael, Schindler, Thomas, Silva, Ana, Ecabert, Barbara, Teixeira, Priscila, Perret, Camille, Reis, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512459/
https://ncbi.nlm.nih.gov/pubmed/28769925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00806
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