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Proton-Coupled Conformational Activation of SARS Coronavirus Main Proteases and Opportunity for Designing Small-Molecule Broad-Spectrum Targeted Covalent Inhibitors

The SARS coronavirus 2 (SARS-CoV-2) main protease (Mpro) is an attractive broad-spectrum antiviral drug target. Despite the enormous progress in structure elucidation, the Mpro’s structure-function relationship remains poorly understood. Recently, a peptidomimetic inhibitor has entered the clinical...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Verma, Neha, Henderson, Jack A., Shen, Jana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754784/
https://ncbi.nlm.nih.gov/pubmed/33320670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10770
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