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Proton-Coupled Conformational Activation of SARS Coronavirus Main Proteases and Opportunity for Designing Small-Molecule Broad-Spectrum Targeted Covalent Inhibitors
The SARS coronavirus 2 (SARS-CoV-2) main protease (Mpro) is an attractive broad-spectrum antiviral drug target. Despite the enormous progress in structure elucidation, the Mpro’s structure-function relationship remains poorly understood. Recently, a peptidomimetic inhibitor has entered the clinical...
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| Publicado en: | J Am Chem Soc |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7754784/ https://ncbi.nlm.nih.gov/pubmed/33320670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10770 |
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