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Orally administered simvastatin partially preserves lumbar vertebral bone mass but not integrity of intervertebral discs in ovariectomized rats

The present study aimed to investigate the effect of orally administered simvastatin on lumbar vertebral bone mass and intervertebral disc (IVD) degeneration in ovariectomized (OVX) rats. A total of 30 female Sprague-Dawley (SD) rats were subjected to either bilateral ovariectomy (n=20) or sham surg...

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Dettagli Bibliografici
Pubblicato in:Exp Ther Med
Autori principali: Tian, Fa-Ming, Li, Shu-Yang, Yang, Kai, Luo, Yang, Dai, Mu-Wei, Liu, Guang-Yuan, Song, Hui-Ping, Zhang, Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403518/
https://ncbi.nlm.nih.gov/pubmed/28450913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2017.4043
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