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Effects of Active Site Mutations on Specificity of Nucleobase Binding in Human DNA Polymerase η
[Image: see text] Human DNA polymerase η (Pol η) plays a vital role in protection against skin cancer caused by damage from ultraviolet light. This enzyme rescues stalled replication forks at cyclobutane thymine–thymine dimers (TTDs) by inserting nucleotides opposite these DNA lesions. Residue R61 i...
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| Publicado no: | J Phys Chem B |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2016
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5402696/ https://ncbi.nlm.nih.gov/pubmed/28423907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b09973 |
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