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Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER–Golgi interface
ERp44 retrieves some endoplasmic reticulum (ER)-resident enzymes and immature oligomers of secretory proteins from the Golgi. Association of ERp44 with its clients is regulated by pH-dependent mechanisms, but the molecular details are not fully understood. Here we report high-resolution crystal stru...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5402435/ https://ncbi.nlm.nih.gov/pubmed/28373561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621426114 |
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