Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations

Charcot–Marie–Tooth disease type 2D (CMT2D) is a peripheral nerve disorder caused by dominant, toxic, gain-of-function mutations in the widely expressed, housekeeping gene, GARS. The mechanisms underlying selective nerve pathology in CMT2D remain unresolved, as does the cause of the mild-to-moderate...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sleigh, James N., Dawes, John M., West, Steven J., Wei, Na, Spaulding, Emily L., Gómez-Martín, Adriana, Zhang, Qian, Burgess, Robert W., Cader, M. Zameel, Talbot, Kevin, Yang, Xiang-Lei, Bennett, David L., Schiavo, Giampietro
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402433/
https://ncbi.nlm.nih.gov/pubmed/28351971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614557114
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