UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

Deafferentation of motor neurons as a result of defective sensory-motor connectivity is a critical early event in the pathogenesis of spinal muscular atrophy, but the underlying molecular pathways remain unknown. We show that restoration of ubiquitin-like modifier-activating enzyme 1 (UBA1) was suff...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Shorrock, Hannah K, van der Hoorn, Dinja, Boyd, Penelope J, Llavero Hurtado, Maica, Lamont, Douglas J, Wirth, Brunhilde, Sleigh, James N, Schiavo, Giampietro, Wishart, Thomas M, Groen, Ewout J N, Gillingwater, Thomas H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158753/
https://ncbi.nlm.nih.gov/pubmed/30239612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy237
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