Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity

Sensing and reacting to tissue damage is a fundamental function of immune systems. Macrophage inducible C-type lectin (Mincle) is an activating C-type lectin receptor that senses damaged cells. Notably, Mincle also recognizes glycolipid ligands on pathogens. To elucidate endogenous glycolipids ligan...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Nagata, Masahiro, Izumi, Yoshihiro, Ishikawa, Eri, Kiyotake, Ryoko, Doi, Rieko, Iwai, Satoru, Omahdi, Zakaria, Yamaji, Toshiyuki, Miyamoto, Tomofumi, Bamba, Takeshi, Yamasaki, Sho
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402399/
https://ncbi.nlm.nih.gov/pubmed/28373578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618133114
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