Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization

Mouse Numb homologs antagonize Notch1 signaling pathways through largely unknown mechanisms. Here we demonstrate that conditional mouse mutants with deletion of numb and numblike in developing sensory ganglia show a severe reduction in axonal arborization in afferent fibers, but no deficit in neurog...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Huang, Eric J., Li, Huashun, Tang, Amy A., Wiggins, Amanda K., Neve, Rachael L., Zhong, Weimin, Jan, Lily Y., Jan, Yuh Nung
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC540232/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15598981/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1246005
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