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Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization
Mouse Numb homologs antagonize Notch1 signaling pathways through largely unknown mechanisms. Here we demonstrate that conditional mouse mutants with deletion of numb and numblike in developing sensory ganglia show a severe reduction in axonal arborization in afferent fibers, but no deficit in neurog...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC540232/ https://ncbi.nlm.nih.gov/pubmed/15598981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1246005 |
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