Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic mdx mouse

Duchenne muscular dystrophy (DMD) is a progressive primary myodegenerative disease caused by a genetic deficiency of the 427-kDa cytoskeletal protein dystrophin. Despite its single-gene etiology, DMD’s complex pathogenesis remains poorly understood, complicating the extrapolation from results of pre...

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Detalles Bibliográficos
Publicado en:J Appl Physiol (1985)
Autores principales: Song, Yafeng, Rosenblum, Shira T., Morales, Leon, Petrov, Mihail, Greer, Christopher, Globerman, Samantha, Stedman, Hansell H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401958/
https://ncbi.nlm.nih.gov/pubmed/27932677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00776.2016
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