Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic mdx mouse

Duchenne muscular dystrophy (DMD) is a progressive primary myodegenerative disease caused by a genetic deficiency of the 427-kDa cytoskeletal protein dystrophin. Despite its single-gene etiology, DMD’s complex pathogenesis remains poorly understood, complicating the extrapolation from results of pre...

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Veröffentlicht in:J Appl Physiol (1985)
Hauptverfasser: Song, Yafeng, Rosenblum, Shira T., Morales, Leon, Petrov, Mihail, Greer, Christopher, Globerman, Samantha, Stedman, Hansell H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5401958/
https://ncbi.nlm.nih.gov/pubmed/27932677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00776.2016
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