The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells

During immune responses, naïve T cells transition from small quiescent cells to rapidly cycling cells. We have found that T cells lacking TAX1BP1 exhibit delays in growth of cell size and cell cycling. TAX1BP1-deficient T cells exited G(0) but stalled in S phase, due to both bioenergetic and biosynt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Whang, Michael I., Tavares, Rita M., Benjamin, Daniel I., Kattah, Michael G., Advincula, Rommel, Nomura, Daniel K., Debnath, Jayanta, Malynn, Barbara A., Ma, Averil
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400745/
https://ncbi.nlm.nih.gov/pubmed/28314591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.02.018
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