Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition

The non-genotoxic nature of proteasome inhibition makes it an attractive therapeutic option for the treatment of pediatric malignancies. We recently described the small molecule VLX1570 as an inhibitor of proteasome deubiquitinase (DUB) activity that induces proteotoxic stress and apoptosis in cance...

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Publicado en:Oncotarget
Autores principales: Mazurkiewicz, Magdalena, Hillert, Ellin-Kristina, Wang, Xin, Pellegrini, Paola, Olofsson, Maria Hägg, Selvaraju, Karthik, D’Arcy, Padraig, Linder, Stig
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400570/
https://ncbi.nlm.nih.gov/pubmed/28423502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15501
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