Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Aims: b-AP15 is a recently described inhibitor of the USP14/UCHL5 deubiquitinases (DUBs) of the 19S proteasome. Exposure to b-AP15 results in blocking of proteasome function and accumulation of polyubiquitinated protein substrates in cells. This novel mechanism of proteasome inhibition may potential...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Brnjic, Slavica, Mazurkiewicz, Magdalena, Fryknäs, Mårten, Sun, Chao, Zhang, Xiaonan, Larsson, Rolf, D'Arcy, Pádraig, Linder, Stig
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2014
Témata:
Forum Original Research CommunicationTargeting the Ubiquitin-Proteasome System (A. Ludwig and O. Drews, Eds.)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241954/
https://ncbi.nlm.nih.gov/pubmed/24011031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5322
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