Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD

TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing...

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Vydáno v:eLife
Hlavní autoři: Mesrouze, Yannick, Bokhovchuk, Fedir, Meyerhofer, Marco, Fontana, Patrizia, Zimmermann, Catherine, Martin, Typhaine, Delaunay, Clara, Erdmann, Dirk, Schmelzle, Tobias, Chène, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400505/
https://ncbi.nlm.nih.gov/pubmed/28430104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25068
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