Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with the strongest signal of selection in p...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Peng, Yi, Cui, Chaoying, He, Yaoxi, Ouzhuluobu, Zhang, Hui, Yang, Deying, Zhang, Qu, Bianbazhuoma, Yang, Lixin, He, Yibo, Xiang, Kun, Zhang, Xiaoming, Bhandari, Sushil, Shi, Peng, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan, Yongyue, Cirenyangji, Baimayangji, Gonggalanzi, Bai, Caijuan, Bianba, Basang, Ciwangsangbu, Xu, Shuhua, Chen, Hua, Liu, Shiming, Wu, Tianyi, Qi, Xuebin, Su, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Discoveries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400376/
https://ncbi.nlm.nih.gov/pubmed/28096303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw280
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