Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with the strongest signal of selection in p...

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Vydáno v:Mol Biol Evol
Hlavní autoři: Peng, Yi, Cui, Chaoying, He, Yaoxi, Ouzhuluobu, Zhang, Hui, Yang, Deying, Zhang, Qu, Bianbazhuoma, Yang, Lixin, He, Yibo, Xiang, Kun, Zhang, Xiaoming, Bhandari, Sushil, Shi, Peng, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan, Yongyue, Cirenyangji, Baimayangji, Gonggalanzi, Bai, Caijuan, Bianba, Basang, Ciwangsangbu, Xu, Shuhua, Chen, Hua, Liu, Shiming, Wu, Tianyi, Qi, Xuebin, Su, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Discoveries
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400376/
https://ncbi.nlm.nih.gov/pubmed/28096303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw280
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