Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance

In vitro-in vivo extrapolation of drug metabolism data obtained in enriched preparations of subcellular fractions rely on robust estimates of physiologically relevant scaling factors for the prediction of clearance in vivo. The purpose of the current study was to measure the microsomal and cytosolic...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Scotcher, Daniel, Billington, Sarah, Brown, Jay, Jones, Christopher R., Brown, Colin D. A., Rostami-Hodjegan, Amin, Galetin, Aleksandra
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399648/
https://ncbi.nlm.nih.gov/pubmed/28270564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.075242
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