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Characterization of In Vitro Glucuronidation Clearance of a Range of Drugs in Human Kidney Microsomes: Comparison with Liver and Intestinal Glucuronidation and Impact of Albumin

Previous studies have shown the importance of the addition of albumin for characterization of hepatic glucuronidation in vitro; however, no reports exist on the effects of albumin on renal or intestinal microsomal glucuronidation assays. This study characterized glucuronidation clearance (CL(int, UG...

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Detalhes bibliográficos
Main Authors: Gill, Katherine L., Houston, J. Brian, Galetin, Aleksandra
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310423/
https://ncbi.nlm.nih.gov/pubmed/22275465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.043984
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