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Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging
Herein we describe fluorescent derivatives of vemurafenib to probe therapeutic BRAF inhibition in live cells and in vivo. The compounds were evaluated and compared by determining target binding, inhibition of mutant BRAF melanoma cell lines and live cell imaging. We show that vemurafenib-BODIPY is a...
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| 發表在: | Theranostics |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Ivyspring International Publisher
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5399591/ https://ncbi.nlm.nih.gov/pubmed/28435463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.18238 |
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