Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal

Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biol Open
Hauptverfasser: Ye, Shoudong, Zhang, Tao, Tong, Chang, Zhou, Xingliang, He, Kan, Ban, Qian, Liu, Dahai, Ying, Qi-Long
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399551/
https://ncbi.nlm.nih.gov/pubmed/28288968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.022426
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