Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal

Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency...

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Detalles Bibliográficos
Publicado en:Biol Open
Main Authors: Ye, Shoudong, Zhang, Tao, Tong, Chang, Zhou, Xingliang, He, Kan, Ban, Qian, Liu, Dahai, Ying, Qi-Long
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399551/
https://ncbi.nlm.nih.gov/pubmed/28288968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.022426
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