Interleukin-6 increases the expression and activity of insulin-degrading enzyme

Impairment of the insulin-degrading enzyme (IDE) is associated with obesity and type 2 diabetes mellitus (T2DM). Here, we used 4-mo-old male C57BL/6 interleukin-6 (IL-6) knockout mice (KO) to investigate the role of this cytokine on IDE expression and activity. IL-6 KO mice displayed lower insulin c...

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發表在:Sci Rep
Main Authors: Kurauti, Mirian A., Costa-Júnior, José M., Ferreira, Sandra M., Santos, Gustavo J., Sponton, Carlos H. G., Carneiro, Everardo M., Telles, Guilherme D., Chacon-Mikahil, Mara P. T., Cavaglieri, Cláudia R., Rezende, Luiz F., Boschero, Antonio C.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399448/
https://ncbi.nlm.nih.gov/pubmed/28429777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46750
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