Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

BACKGROUND: Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK2 plays a pivotal role in tumor initiation and maintenance, which provides a ne...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Li, Wei, Zheng, Mengzhu, Wu, Shuangping, Gao, Suyu, Yang, Mei, Li, Zhimei, Min, Qiuxia, Sun, Weiguang, Chen, Lixia, Xiang, Guangya, Li, Hua
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399312/
https://ncbi.nlm.nih.gov/pubmed/28427443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0530-4
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