Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

BACKGROUND: Pyroptosis is a lytic cell death form executed by gasdermins family proteins. Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer treatment strategy. Triptolide (TPL) is a natural product isolated from the traditional Chinese herb which possesses potent a...

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Bibliografske podrobnosti
izdano v:J Exp Clin Cancer Res
Main Authors: Cai, Jing, Yi, Mei, Tan, Yixin, Li, Xiaoling, Li, Guiyuan, Zeng, Zhaoyang, Xiong, Wei, Xiang, Bo
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188724/
https://ncbi.nlm.nih.gov/pubmed/34108030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01995-7
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