A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice

The targeting of two independent but synergistic enzymatic activities, histone deacetylases (HDACs, class I and HDAC6) and phosphodiesterase 5 (PDE5), has recently been validated as a potentially novel therapeutic approach for Alzheimer's disease (AD). Here we report the discovery of a new firs...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Cuadrado-Tejedor, Mar, Garcia-Barroso, Carolina, Sánchez-Arias, Juan A, Rabal, Obdulia, Pérez-González, Marta, Mederos, Sara, Ugarte, Ana, Franco, Rafael, Segura, Victor, Perea, Gertrudis, Oyarzabal, Julen, Garcia-Osta, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399234/
https://ncbi.nlm.nih.gov/pubmed/27550730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.163
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