A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurodevelopment and a prominent candidate protein in the pathology of major mental illness. DISC1 modulates a number of critical neuronal signaling pathways through protein-protein interactions; however, the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yerabham, Antony S. K., Mas, Philippe J., Decker, Christina, Soares, Dinesh C., Weiergräber, Oliver H., Nagel-Steger, Luitgard, Willbold, Dieter, Hart, Darren J., Bradshaw, Nicholas J., Korth, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399101/
https://ncbi.nlm.nih.gov/pubmed/28249940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773903
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