The mammalian autophagy initiator complex contains 2 HORMA domain proteins

ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fol...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Michel, Max, Schwarten, Melanie, Decker, Christina, Nagel-Steger, Luitgard, Willbold, Dieter, Weiergräber, Oliver H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
Soggetti:
Basic Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835198/
https://ncbi.nlm.nih.gov/pubmed/26236954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1076605
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