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Mini-G proteins: Novel tools for studying GPCRs in their active conformation
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G proteins, and their ease of expression and purification,...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5398546/ https://ncbi.nlm.nih.gov/pubmed/28426733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175642 |
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