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Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps

Genetic maps in linkage disequilibrium (LD) units play the same role for association mapping as maps in centimorgans provide at much lower resolution for linkage mapping. Association mapping of genes determining disease susceptibility and other phenotypes is based on the theory of LD, here applied t...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zhang, Weihua, Collins, Andrew, Gibson, Jane, Tapper, William J., Hunt, Sarah, Deloukas, Panos, Bentley, David R., Morton, Newton E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC539799/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15604137/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408251102
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