Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps

Genetic maps in linkage disequilibrium (LD) units play the same role for association mapping as maps in centimorgans provide at much lower resolution for linkage mapping. Association mapping of genes determining disease susceptibility and other phenotypes is based on the theory of LD, here applied t...

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Bibliographic Details
Main Authors: Zhang, Weihua, Collins, Andrew, Gibson, Jane, Tapper, William J., Hunt, Sarah, Deloukas, Panos, Bentley, David R., Morton, Newton E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC539799/
https://ncbi.nlm.nih.gov/pubmed/15604137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408251102
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