Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps

Genetic maps in linkage disequilibrium (LD) units play the same role for association mapping as maps in centimorgans provide at much lower resolution for linkage mapping. Association mapping of genes determining disease susceptibility and other phenotypes is based on the theory of LD, here applied t...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Zhang, Weihua, Collins, Andrew, Gibson, Jane, Tapper, William J., Hunt, Sarah, Deloukas, Panos, Bentley, David R., Morton, Newton E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC539799/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15604137/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408251102
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