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Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment

Members of the voltage-gated-like ion channel superfamily have a conserved pore structure. Transmembrane helices that line the pore (M2 or S6) are thought to gate it at the cytoplasmic end by bending at a hinge glycine residue. Proline residues favor bending of α-helices, and substitution of proline...

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Autori principali: Zhao, Yong, Scheuer, Todd, Catterall, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC539779/
https://ncbi.nlm.nih.gov/pubmed/15583130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408270101
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