Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment
Members of the voltage-gated-like ion channel superfamily have a conserved pore structure. Transmembrane helices that line the pore (M2 or S6) are thought to gate it at the cytoplasmic end by bending at a hinge glycine residue. Proline residues favor bending of α-helices, and substitution of proline...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC539779/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15583130/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408270101 |
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