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Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment
Members of the voltage-gated-like ion channel superfamily have a conserved pore structure. Transmembrane helices that line the pore (M2 or S6) are thought to gate it at the cytoplasmic end by bending at a hinge glycine residue. Proline residues favor bending of α-helices, and substitution of proline...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC539779/ https://ncbi.nlm.nih.gov/pubmed/15583130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408270101 |
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