Asunaprevir Evokes Hepatocytes Innate Immunity to Restrict the Replication of Hepatitis C and Dengue Virus

Type I Interferon-mediated innate immunity against Flaviviridae, such as Hepatitis C virus (HCV) and Dengue virus (DENV), involves TLR3, RIG-I-like receptor (RLR) and JAK-STAT signal pathways. Asunaprevir is a newly developed HCV protease inhibitor for HCV treatment. Whether, asunaprevir activates i...

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Dettagli Bibliografici
Pubblicato in:Front Microbiol
Autori principali: Tsai, Wei-Lun, Cheng, Jin-Shiung, Shu, Chih-Wen, Lai, Kwok-Hung, Chan, Hoi-Hung, Wu, Chun-Ching, Wu, Jing-Mei, Hsu, Ping-I, Chung, Raymond T., Chang, Tsung-Hsien
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397474/
https://ncbi.nlm.nih.gov/pubmed/28473813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.00668
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