Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase

Activation of the type I interferon (IFN) signaling pathway is essential for the eradication of hepatitis C virus (HCV). Metformin can activate adenosine monophosphate-activated protein kinase (AMPK) to reduce insulin resistance. Cross talks between AMPK and IFN signaling remain unclear. To understa...

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Vydáno v:Oncotarget
Hlavní autoři: Tsai, Wei-Lun, Chang, Tsung-Hsien, Sun, Wei-Chi, Chan, Hoi-Hung, Wu, Chun-Ching, Hsu, Ping-I, Cheng, Jin-Shiung, Yu, Ming-Lung
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696152/
https://ncbi.nlm.nih.gov/pubmed/29190886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20248
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