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TM6SF2 rs58542926 impacts lipid processing in liver and small intestine

The transmembrane 6 superfamily member 2 (TM6SF2) loss-of-function variant, rs58542926, is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis, but is paradoxically associated with lower levels of hepatic-derived triglyceride-rich lipoproteins (TRLs). TM6SF2 is exp...

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Bibliografische gegevens
Gepubliceerd in:Hepatology
Hoofdauteurs: O’Hare, Elizabeth A., Yang, Rongze, Yerges-Armstrong, Laura, Sreenivasan, Urmilla, McFarland, Rebecca, Leitch, Carmen C., Wilson, Meredith H., Narina, Shilpa, Gorden, Alexis, Ryan, Kathy, Shuldiner, Alan R., Farber, Steve A., Wood, G. Craig, Still, Christopher D., Gerhard, Glenn S., Robishaw, Janet D., Sztalryd, Carole, Zaghloul, Norann A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397347/
https://ncbi.nlm.nih.gov/pubmed/28027591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29021
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