TM6SF2 rs58542926 impacts lipid processing in liver and small intestine

The transmembrane 6 superfamily member 2 (TM6SF2) loss-of-function variant, rs58542926, is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis, but is paradoxically associated with lower levels of hepatic-derived triglyceride-rich lipoproteins (TRLs). TM6SF2 is exp...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: O’Hare, Elizabeth A., Yang, Rongze, Yerges-Armstrong, Laura, Sreenivasan, Urmilla, McFarland, Rebecca, Leitch, Carmen C., Wilson, Meredith H., Narina, Shilpa, Gorden, Alexis, Ryan, Kathy, Shuldiner, Alan R., Farber, Steve A., Wood, G. Craig, Still, Christopher D., Gerhard, Glenn S., Robishaw, Janet D., Sztalryd, Carole, Zaghloul, Norann A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397347/
https://ncbi.nlm.nih.gov/pubmed/28027591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29021
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