Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication

We recently identified the 4-pyridinone-benzisothiazole carboxamide compound 1C8 as displaying strong anti-HIV-1 potency against a variety of clinical strains in vitro. Here we show that 1C8 decreases the expression of HIV-1 and alters splicing events involved in the production of HIV-1 mRNAs. Altho...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Shkreta, Lulzim, Blanchette, Marco, Toutant, Johanne, Wilhelm, Emmanuelle, Bell, Brendan, Story, Benjamin A., Balachandran, Ahalya, Cochrane, Alan, Cheung, Peter K., Harrigan, P. Richard, Grierson, David S., Chabot, Benoit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
RNA
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397194/
https://ncbi.nlm.nih.gov/pubmed/27928057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1223
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