SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors

RNA binding proteins and signaling components control the production of pro-death and pro-survival splice variants of Bcl-x. DNA damage promoted by oxaliplatin increases the level of pro-apoptotic Bcl-xS in an ATM/CHK2-dependent manner, but how this shift is enforced is not known. Here, we show that...

Full description

Saved in:
Bibliographic Details
Published in:Cell Rep
Main Authors: Shkreta, Lulzim, Toutant, Johanne, Durand, Mathieu, Manley, James L., Chabot, Benoit
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483951/
https://ncbi.nlm.nih.gov/pubmed/27851963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.071
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items