Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis

BACKGROUND: Osteoarthritis (OA) is manifested by synovial inflammation and cartilage destruction that is directly linked to synovitis, joint swelling and pain. In the light of the role of synovium in the pathogenesis and the symptoms of OA, synovium-targeted therapy is a promising strategy to mitiga...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Kuo, Shu-Jui, Yang, Wei-Hung, Liu, Shan-Chi, Tsai, Chun-Hao, Hsu, Horng-Chaung, Tang, Chih-Hsin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397058/
https://ncbi.nlm.nih.gov/pubmed/28423042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176052
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