Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways

INTRODUCTION: Thrombin is a key factor in the stimulation of fibrin deposition, angiogenesis, and proinflammatory processes. Abnormalities in these processes are primary features of osteoarthritis (OA). Heme oxygenase (HO)-1 is a stress-inducible rate-limiting enzyme in heme degradation that confers...

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Autores principales: Liu, Ju-Fang, Hou, Sheng-Mou, Tsai, Chun-Hao, Huang, Chun-Yin, Yang, Wei-Hung, Tang, Chih-Hsin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446465/
https://ncbi.nlm.nih.gov/pubmed/22541814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3815
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