β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity

ICOS costimulation generates Th17 cells with durable memory responses to tumor. Herein, we found that ICOS induces PI3K/p110δ/Akt and Wnt/β-catenin pathways in Th17 cells. Coinhibiting PI3Kδ and β-catenin altered the biological fate of Th17 cells. Th17 cells inhibited of both pathways expressed less...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Majchrzak, Kinga, Nelson, Michelle H., Bowers, Jacob S., Bailey, Stefanie R., Wyatt, Megan M., Wrangle, John M., Rubinstein, Mark P., Varela, Juan C., Li, Zihai, Himes, Richard A., Chan, Sherine S.L., Paulos, Chrystal M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396523/
https://ncbi.nlm.nih.gov/pubmed/28422756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90547
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