β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity

ICOS costimulation generates Th17 cells with durable memory responses to tumor. Herein, we found that ICOS induces PI3K/p110δ/Akt and Wnt/β-catenin pathways in Th17 cells. Coinhibiting PI3Kδ and β-catenin altered the biological fate of Th17 cells. Th17 cells inhibited of both pathways expressed less...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Majchrzak, Kinga, Nelson, Michelle H., Bowers, Jacob S., Bailey, Stefanie R., Wyatt, Megan M., Wrangle, John M., Rubinstein, Mark P., Varela, Juan C., Li, Zihai, Himes, Richard A., Chan, Sherine S.L., Paulos, Chrystal M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396523/
https://ncbi.nlm.nih.gov/pubmed/28422756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90547
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak