Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion

Adoptive immunotherapy for solid tumors relies on infusing large numbers of T cells to mediate successful antitumor responses in patients. While long-term rapid-expansion protocols (REPs) produce sufficient numbers of CD8(+) T cells for treatment, they also cause decline in the cell’s therapeutic fi...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Bowers, Jacob S., Nelson, Michelle H., Majchrzak, Kinga, Bailey, Stefanie R., Rohrer, Baerbel, Kaiser, Andrew D.M., Atkinson, Carl, Gattinoni, Luca, Paulos, Chrystal M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333954/
https://ncbi.nlm.nih.gov/pubmed/28289713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90772
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