MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections

Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2–deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1(+/–) hetero...

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Vydáno v:JCI Insight
Hlavní autoři: McCormack, Ryan M., Szymanski, Eva P., Hsu, Amy P., Perez, Elena, Olivier, Kenneth N., Fisher, Eva, Goodhew, E. Brook, Podack, Eckhard R., Holland, Steven M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396519/
https://ncbi.nlm.nih.gov/pubmed/28422754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89635
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