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Peripheral viral challenge elevates extracellular glutamate in the hippocampus leading to seizure hypersusceptibility

Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We have modeled this comorbidity by demonstrating that the acute phase response (APR) instigated by an intraperitoneal (i.p.) injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC), induces...

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Bibliografiske detaljer
Udgivet i:J Neurochem
Main Authors: Hunsberger, Holly C., Konat, Gregory W., Reed, Miranda N.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395347/
https://ncbi.nlm.nih.gov/pubmed/28244106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13999
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