MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice

BACKGROUND: By the time clinical symptoms of Alzheimer’s disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several gro...

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Vydáno v:Vaccine
Hlavní autoři: Davtyan, Hayk, Chen, Wesley W., Zagorsky, Karen, Davis, Joy, Petrushina, Irina, Kazarian, Konstantin, Cribbs, David H., Agadjanyan, Michael G., Blurton-Jones, Mathew, Ghochikyan, Anahit
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395280/
https://ncbi.nlm.nih.gov/pubmed/28320590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.03.020
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