PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility

Bobby sox homolog (Bbx) is an evolutionally conserved gene, but its biological function remains elusive. Here, we characterized defects of Bbx mutant rats that were created by PiggyBac-mediated insertional mutagenesis. Smaller body size and male infertility were the two major phenotypes of homozygou...

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Bibliografiske detaljer
Udgivet i:Biol Reprod
Main Authors: Wang, Chieh-Ying, Tang, Ming-Chu, Chang, Wen-Chi, Furushima, Kenryo, Jang, Chuan-Wei, Behringer, Richard R, Chen, Chun-Ming
Format: Artigo
Sprog:Inglês
Udgivet: Society for the Study of Reproduction, Inc. 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394979/
https://ncbi.nlm.nih.gov/pubmed/27465138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.116.141739
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