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PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility

Bobby sox homolog (Bbx) is an evolutionally conserved gene, but its biological function remains elusive. Here, we characterized defects of Bbx mutant rats that were created by PiggyBac-mediated insertional mutagenesis. Smaller body size and male infertility were the two major phenotypes of homozygou...

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Detalhes bibliográficos
Publicado no:Biol Reprod
Main Authors: Wang, Chieh-Ying, Tang, Ming-Chu, Chang, Wen-Chi, Furushima, Kenryo, Jang, Chuan-Wei, Behringer, Richard R, Chen, Chun-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394979/
https://ncbi.nlm.nih.gov/pubmed/27465138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.116.141739
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